INVITED SESSIONS

IS: Emerging micro- and nano-scale sensing and manipulation techniques

Session Chair: Tim Yeh, Biomedical Engineering Department, University of Texas at Austin, Austin, Texas, USA

This session will focus on exciting emerging microscale and nanoscale technologies for molecular, cellular and tissue level studies. The topics range from novel photonic sensors, microfluidic systems for tissue culture, nanopore measurements, and membrane receptor trajectory acquisition and analysis. Both early-stage conceptual investigation and translational work will be presented.

Assessing metastatic potential and classifying cancer cells using deep learning-based EGFR trajectory analysis, Yen-Liang Liu, Master Program for Biomedical Engineering, China Medical University, Taichung City, Taiwan

Using the next-generation sequencing platform for massively parallel selection of fluorescent nanomaterials, Tim Yeh, Biomedical Engineering Department, University of Texas at Austin, TX, USA

Resistive pulse nanopore sensing for single-molecule and single-particle analysis, MinJun Kim, Mechanical Engineering Department, Southern Methodist University, TX, USA

Microfluidic chip-based method for cell spheroids culture, Chia-Hsien Hsu, Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan

IS: Nanoconstructs for biosensing and cellular engineering

Session Chair: Aram Chung, Korea University

This session introduces novel nanoparticles and nanodevices for biosensing and cellular engineering applications.

Plasmonic Nanostructures for Sensitive Molecular Sensing and High-Spatial Imaging, Inhee Choi,Department of Life Science, University of Seoul, Seoul, Korea

Nanoparticles for Intracellular Glucose Monitoring, Yun Jung Heo, Department of Mechanical Engineering, Kyung Hee University, Gyeonggido, Republic of Korea

Metal-organic framework nanoparticle-embedded functional platform to guide neural stem cell differentiation, Tae-Hyung Kim, School of Integrative Engineering, Chung-Ang University, Seoul, Korea

Dielectrophoretic underwater capture and detection of ultra-low concentrated nanoparticles, Yong-Sang Ryu, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea, KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea

IS: Novel Micro/Nano Systems for Bio and Energy Applications

Session Chair: Sung-Yong Park, Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA

Microfluidics for Environmental application: Monitoring harmful microorganisms and biofilm formation in microfluidic chips , Sungwoo Bae , Department of Civil and Environmental Engineering, National University of Singapore, Singapore

Selective artificial neural network by targeted delivery of neuronal cells using magnetically controlled microrobots, Hongsoo Choi, Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, South Korea. DGIST-ETH Microrobotics Research Center, DGIST, Daegu 42988, South Korea. Robotics Research Center, DGIST, Daegu 42988, South Korea

A novel microsensor embedded coronary artery stent to continuously monitor in-stent restenosis , Moataz Elsisy¹ , Robert Herbert² , Woon-Hong Yeo^2,3,4, Mohamed Ibrahim¹ , Youngjae Chun^1,5,6*,

¹Department of Industrial Engineering, University of Pittsburgh, PA 15261, USA

²George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA

³Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30322, USA

⁴Parker H. Petit Institute for Bioengineering and Biosciences, Institute for Materials, Neural Engineering Center, Institute for Robotics and Intelligent Machines, Georgia Institute of Technology, Atlanta, GA 30332, USA

⁵McGowan Center for Regenerative Medicine, University of Pittsburgh Medical Center, PA 15213, USA, 6Department of Bioengineering, University of Pittsburgh, PA 15261, USA

An optofluidic solar indoor lighting for green and sustainable buildings ,Sung-Yong (Sean) Park , Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA

Novel computational design of high refractive index nanocomposites and effective refractive index tuning based on nanoparticle morphology effect , Jong Eun Ryu, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA

IS: Advanced Bioelectronics and Biointerfaces

Session Chair: Huiliang Wang, Department of Biomedical Engineering, University of Texas at Austin

Bioelectronics and Biointerfaces is a rapidly growing field that utilizes advanced materials and electronic systems to bidirectionally interface with biological systems. Such bioelectronic systems can be applied not only for deeper understanding of basic brain functions but also for enhanced diagnostics, monitoring and therapeutics in human disease. In this session, we will have five invited speakers to discuss about the design of advanced nanomaterials, organic materials, device fabrication strategies for improved bio-interfacing capability.

Multifunctional Integrated Nanoelectronics for the Brain, Hui Fang, Thayer School of Engineering, Dartmouth College, Hanover, NH, USA

Seeing the Sound: Wireless Neural Interfaces for In Vivo Neuromodulation, Guosong Hong, Department of Materials Science and Engineering, Stanford University, CA, USA , Wu Tsai Neurosciences Institute, Stanford University, CA, USA

Design of Advanced Wearable EEG Electrodes for Brain-Computer Interface, Huiliang Wang, Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA

Smart Textiles for Personalized Health Care, Jun Chen, Bioengineering Department, University of California at Los Angeles, CA, USA

Skin-Interfaced Wearable Biosensors, Wei Gao, Senior member, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA 91125, USA

IS: NEMS Emerging Applications

Session Chair: Mark Cheng, The University of Alabama

Micro/nano microsystems have found many applications in recent years. In this section, the invited speakers will discuss on-going research in their research group, including label-free detection (called SHRED) for water-in-oil droplet systems, to 3D printed microfluidic microfluidic, and to microplastic detection based on computer vision and machine learning. The section will also cover quantum computer connectors using electrodeposited superconductor and parity-time symmetric wireless sensing for biomedical devices.

Chemical Detection in Droplets using the
Stagnant-Cap Hydrodynamic Retardation Effect Detector (SHRED), Amar S. Basu, Professor, Electrical and Computer Engineering and Biomedical Engineering
Wayne State University, Detroit MI, USA

Monolithically 3D-Printed Microfluidics with Wirelessly-Driven Boundary Layer Pump, Joe Fujiou Lo, Mechanical Engineering Department, University of Michigan at Dearborn, MI, USA

Microfluidic for In-line Microplastic Detection, Mark Cheng, Professor, Electrical and Computer Engineering, The University of Alabama, Tuscaloosa

Electrodeposited Superconductor Thin Films for the Fabrication of Quantum Computer Connectors, Qiang Huang, Department of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, USA

Higher-Order PT-Symmetric Telemetry for Wireless Microsensors, Pai-Yen Chen, Department of Electrical and Computer Engineering, University of Illinois at Chicago, IL, USA

IS: Functional materials and NEMS/MEMS

Session Chair: Akio Higo, d.lab, the University of Tokyo

This invited session shows the functional materials and NEMS/MEMS for future integration of materials and devices. We selected in simulation field, nano-material field, NEMS/MEMS field, Bio-related device field, and compound semiconductor field. We discuss the material characteristics and future integration of the functional materials to NEMS/MEMS and colloidal quantum dots solar cell devices.

Molecular Analyses of Transport Phenomena of Reactant/Product Materials in Polymer Electrolyte Fuel Cell, Takashi Tokumasu¹, Takuya Mabuchi²

¹Institute of Fluid Science, Tohoku University, Sendai, Japan

²Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan

Photoelectric conversion using Infrared absorbing colloidal nanocrystals, Haibin Wang¹, Takaya Kubo², and Hiroshi Segawa^{1, 2}

¹Graduate School Arts & Sciences, The University of Tokyo, Tokyo, Japan.

²Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

Beyond Nanomaterials: The Science of Subnanometer Particles, Takane Imaoka, Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Japan., School of Materials and Chemical Technology, Tokyo Institute of Technology, Japan

Tailor-made CMOS-MEMS as tools for nanomaterials, Yoshio Mita, Senior Member, Department of Electrical Engineering and Information Systems (EEIS), the University of Tokyo, Japan., Platform Device Research Division, Systems Design Lab., School of Engineering, the University of Tokyo, Japan

Bio-sensor Using Electrochemical Impedance Spectroscopy, Ichiro Yamashita, Graduate School of Medicine, Osaka University, 8-1 MihogaOka Suita, Osaka, Japan

IS: Biomaterials and Biosensors in Biomedical Application

Session Chair: Yu-Jui (Ray) Fan, School of Biomedical Engineering, Taipei Medical University, Taiwan

Description: In recent years, a great deal of focus has been aimed to engineer biomaterial-based cues, both at the micro/nano scales, and biosensors with applied perspectives for target applications in different bio- and non-bio sectors of the modern world. The key scientific advancements in biomedical area, have presented next generation concepts related to biomaterials. Use of properly designed and structured materials, allows for the development well-defined sensing prototype that supports a series of directed events. For these reasons, we are pleased to launch the invited session and the issue is focused on “biomaterials and biosensors in biomedical application”.

The effect of cyclic mechanical stretch on the 3D culture model of lung cancer cells, Yi –Chiung Hsu, Department of Biomedical Sciences and Engineering, National Central University, Taiwan.

Surface Properties of Nanoparticles Influencing its distribution in eye, Ching-Li Tseng, Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Taipei, Taiwan

Phase-Dependent MoS2 Nanoflowers as Light-Activated Antibacterial Agents,Tsung-Rong Kuo, Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan

Phototherapeutic performances of functional biomaterials, Er-Yuan Chuang, Taipei Medical University, Taiwan

Biosensing platforms with nanostructure surface plasmon resonance for nuclear acid sensing and immunosensing, Yu-Jui Fan, School of Biomedical Engineering, Taipei Medical University, Taiwan

IS: Micro/Nano Biosensing Technologies: From Diseases Diagnostics to Health Monitoring

Session Chair:  Prof. Tak-Sing Wong, The Pennsylvania State University

Detection and diagnosis of critical diseases such as cancer and infectious diseases rely on the ability to detect biological signatures at the cellular and molecular levels. Advancements in micro- and nanotechnologies allow us to detect, monitor, and quantify these biological signatures with unprecedented sensitivity and speed. In this session, we will sample through some of the state-of-the-art biosensing technologies using advanced micro/nanotechnologies ranging from single cell biosensors for cancer study to protein-based biosensors for COVID-19 diagnostics to advanced non-invasive health monitoring.

Ultrasensitive Biomolecular Detection Enabled by Pitcher-Plant-Inspired Slippery Surfaces, Tak-Sing Wong, Department of Mechanical Engineering and the Materials Research Institute, The Pennsylvania State University, PA, USA., Convergence Center for Living Multifunctional Material Systems, The Pennsylvania State University, PA, USA

Targeting Bladder Cancer Heterogeneity by Single Cell Biosensors, Pak Kin Wong, PhD, Professor of Biomedical Engineering, Mechanical Engineering and Surgery, The Pennsylvania State University

Modifying Paper’s Wicking Properties for Microfluidic Paper-Based Sensors, Hideaki Tsutsui, Departments of Mechanical Engineering and Bioengineering, Stem Cell Center, University of California Riverside, USA

Magneto-Immunoassays for Rapid, High Sensitivity Quantification of Protein Biomarkers, Peter B. Lillehoj, Department of Mechanical Engineering, Rice University, Houston, TX, USA., Department of Bioengineering, Rice University, Houston, TX, USA

Plenty of Room Under the Skin: A Wearable’s Perspective, Sheng Xu, Department of Nanoengineering, University of California, San Diego, USA

IS: Microfluidic platforms for cell manipulation and biomarker detection

Session Chair:  Ting-Hsuan Chen, Department of Biomedical Engineering, City University of Hong Kong

Leveraging the microfluidics enables unprecedented accessibility for research in the small scale. In this invited session, we provide a venue for discussing an array of micro/nano devices with factors ranging from fluidic, optic, and nanomaterials for investigation of biological research such as cell manipulation and biomarker detection. It is anticipated to bring inspiration propelling research with new perspectives.

A Novel Photo-Responsive Surfactant for Droplet Microfluidics, Guangyao Cheng¹, To Ngai², Yi-Ping Ho¹

¹Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong

²Department of Chemistry, The Chinese University of Hong Kong, Hong Kong

Predicting Cell Cycle of Live Cells in Detachable Microfluidics with Mask Regional Convolutional Neural Networks, Hsieh-Fu Tsai, Department of Biomedical Engineering, Chang Gung University, Taiwan

The microfluidic system integrating surface-enhanced Raman spectroscopy for antimicrobial susceptibility testing, Nien-Tsu Huang, Department of Electrical Engineering & Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University

Efficient fabrication of monodisperse hepatocyte spheroids and encapsulation in hybrid hydrogel with controllable extracellular matrix effect, Hon Fai Chan, Institute for Tissue Engineering and Regenerative Medicine & School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People’s Republic of China

Microfluidic Particle Dam for Direct Visualization of SARS-CoV-2 Antibody Levels in COVID-19 Vaccinees, Ting-Hsuan Chen, Member, Departments of Biomedical Engineering, City University of Hong Kong, Hong Kong

IS: Wearable and Implantable NanoEnergy and NanoSystem (NENS)

Session Chair: Chengkuo Lee, National University of Singapore

Wearable, flexible and implantable electronics have been developed as self-powered and self-sustained nanosystems with diversified applications, such as human motions sensing, environmental monitoring, healthcare monitoring, therapy, rehabilitation, human-machine interfaces, and factory automation. The future development of NanoEnergy and NanoSystems (NENS) will change the research landscape of wearable and implantable electronics. This invited session presents you the leading works in this area.

Self-powered Medical Devices and Electrical Stimulation Therapy, Zhou LI, Beijing Institute of Nanoenergy and Nanosystems, University of Chinese Academy of Sciences, Beijing, China

Optical Transduction Mechanism Towards Self-Powered Soft Pressure and Strain Sensors, Inkyu Park, Korea Advanced Institute of Science and Technology (KAIST), South Korea

Advanced Multimaterial Fibers: Structure-Enabled Self-Powered Functionalities, Lei Wei, Nanyang Technological University, Singapore

Self-driven Nanomaterials, Devices and Systems for Healthcare and Environmental Applications, Zong-Hong Lin, National Tsing Hua University, Hsinchu, Taiwan

From triboelectric nanogenerators and electronic skins to actively-perceiving soft robots and autonomous flexible applications, Ying-Chih Lai, National Chung Hsing University, Taiwan

IS: Engineering-Based Microphysiological System (MPS): From Fundamentals to Commercial Applications

Session Chair: Ryuji Yokokawa, Kyoto University

Microphysiological system (MPS) is recognized as a microfluidic chip that replicate patho/physiologically relevant cell culture environment toward the evaluation of numerus candidate drugs. Focus of engineering-based researchers in MPS are widely ranging from fundamental academic research to commercial applications: To develop a novel assay platform for understanding biological questions, to develop a prototype for commercialization and to implement industrial use by bridging end users in a regulatory context. Speakers in this session will introduce recent activities of MPS in Japan.

Microphysiological Systems (MPS) Based-on Microfluidic Devices for Commercialization, Hiroshi Kimura^1,2

¹Department of Mechanical Engineering, School of Engineering, Tokai University, Kanagawa, Japan

²Micro/Nano Technology Center, Tokai University, Kanagawa, Japan

Reverse Bioengineering of Living Systems for Drug Discovery, Ken-ichiro Kamei, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Japan

Co-culturing of Epithelial and Endothelial Tissues in Microfluidic Devices Toward SARS-CoV-2 Analysis, Kazuya Fujimoto, Department of Micro Engineering, Kyoto University, Kyoto, Japan

A Triculture Model of the Blood-Brain Barrier for Assessing the Effect of Cell-Cell Interactions on Barrier Integrity, Kennedy Omondi Okeyo^1,2, Ryutaro Tamai², and Taiji Adachi^1,2

¹Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

²Department of Micro Engineering, Kyoto University, Kyoto, Japan

IS: Smart Mechatronics for Energy Harvesting

Session Chair: Daisuke Yamane, Ritsumeikan University

Energy harvesting is one of the key technologies for realizing self-powered, maintenance-free, and autonomous wireless network systems for the coming next-generation Internet of Things era. The technological advancement of energy harvesting devices/systems can be achieved by the development of both mechanical and electrical aspects. This is because one characteristic affects the other, and the performance of energy harvesting devices/systems is related to the performance of both. With this background, this session will focus on state-of-the-art mechatronics technologies for energy harvesting and will cover a wide range of topics including materials, mechanics, electronics, fabrication processes, and applications.

Development of Vibrational Energy Harvester Based on Smart Mechatronics, Shimpei Ono, Central Research Institute of Electric Power Industry, Kanagawa, Japan

Smart electret composed of polar organic molecules for vibrational energy generators, Yuya Tanaka, Center for Frontier Science, Chiba University, Japan

Smart mechatronics for electrostatic MEMS vibration energy harvesters, Daisuke Yamane, Department of Mechanical Engineering, Ritsumeikan University, Shiga, Japan

Smart energy extraction from energy harvesters using timing-based asynchronous digital circuits, Takeaki Yajima, Department of Electrical Engineering and Computer Science, Kyushu University, Fukuoka, Japan

Smart mechatronics based on piezoelectric polymer energy harvesting, Takashi Nakajima, Department of Applied Physics, Faculty of Science, Tokyo University of Science, Tokyo, Japan

IS: Enhanced Non-Enzymatic Microfluidic Biofuel Cells to Continuously Self-Power Bio-devices

Session Chair: Sanket Goel, MEMS, Microfluidics and Nanoelectronics (MMNE) Lab, Department of Electrical and Electronics Engineering Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad, India

Realization of microfluidic non-enzymatic biofuel cells (MNEBFC) has extended attention to power several bioelectronics devices due to their excellent repeatability, high stability, biocompatibility and low-cost. Evidently, for these devices, the utilization of rapidly prototyped fabrication methods, based on 3D printable polymers and paper based devices, have further enhanced their usability with several challenges yet to be resolved. For the bioelectrodes of these devices, noble metals act as catalysts and carbon-based nanomaterials act as support structures. However, such modified surfaces on these substrates are not efficient as they have inadequate catalytic properties to harvest optimal energy. Therefore, there is a necessity to advance the development of nanomaterials, particularly 2D nanomaterials, and modified fabrication methods to facilitate enhanced bioelectrodes for MNEBFC. Herein, the recent novel work on developing non-enzymatic bioelectrodes on 3D printable paper and polymer substrates by leveraging suitable nanomaterials as catalyst and 2D materials, like laser induced graphene, as support material to enhance the electron efficacy. The complete microfluidic device with integrated microchannel and bioelectrodes has been packaged, and such MNEBFC was successfully studied by electrochemical characterization for efficient biocatalysis of glucose producing benchmarked energy. This work paves the way for future rapidly prototyped microfluidic non-enzymatic biofuel cells by incorporating noble metal catalyst and nanomaterial-based supports to operate self-powered bioelectronics devices.

IS: Microneedles

Session Chair: Zhihong Li, Peking University

Microneedles are able to penetrate into the tissue and offer great chances in various biomedical applications including transdermal drug delivery, stable bio-signal monitoring, sampling and bio-sensing. Owing to the micro-scale feature size, microneedles have advantages of minimal invasiveness, painlessness, high biosafety and simple operation. Our invited speakers will share their excellent research on materials, fabrication technologies and applications on various microneedles.

Minimally invasive bioelectronics, Xi Xie, Sun Yat-sen University, China

Microneedles for applications of biomedical engineering, Jingquan Liu, Shanghai Jiaotong University, China

Silk microneedle patch capable of on-demand multidrug delivery to the brain for glioblastoma treatment, Tiger Hu Tao, SIMIT CAS, China

Polycrystalline diamond-based microelectrodes for neurotransmitter sensing, Wen Li, Michigan State University, USA

Microneedle based Nanoelectroporation for localized gene delivery in vivo, Lingqian Chang, Beihang University, China

IS: The impact of interdisciplinary science

Session Chair: Tzu-En Lin, Dept of Electronics and Computer Engineering, Int. of Biomedical Engineering, National Yang Ming Chiao Tung University, Taiwan

The session is dedicated to providing a forum to discuss the latest developments in all areas of science and engineering, especially in fields of chemistry, chemical engineering, biomedical engineering.

Triboelectric field-enabled switching structures in cholesteric liquid crystals for self-powered applications of information security and vision correction, Zong-Hong Lin, Institute of Biomedical Engineering, Department of Power Mechanical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan

Microfluidic Analytical Systems for Disease Diagnosis, Chien-Fu Chen, Institute of Applied Mechanics at National Taiwan University, Taiwan

The application of fungal polysaccharides on anti-cancer, Tung-Yi Lin, Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Program in Molecule Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, Taiwan

Single-molecule Analytical Platform for Nanoscience and Chemical/Biological Applications, Peng Zhang, Water Desalination and Reuse Center, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, 23955, Thuwal, Saudi Arabia

AI-Based Scanning Electrochemical Microscopy Image Fusion using Novel Soft Ultramicroelectrode, Tzu-En Lin, Dept of Electronics and Computer Engineering, Int. of Biomedical Engineering, National Yang Ming Chiao Tung University, Taiwan

IS: Advanced Nanofluidic Systems for Single Molecule Detection

Session Chair: Wei-Lun Hsu, Department of Mechanical Engineering, The University of Tokyo, Tokyo, Japan

Understanding intricate and coupled electrokinetic and electrochemical phenomena in nanospace is of crucial importance for single molecule detection toward next generation of medical diagnostic applications. In this session, we invite five exceptional talks on nanofluidics for biosensing research from young and inspiring scientists in Japan, P. R. China and Taiwan (R. O. C.), covering the cutting-edge topics of nanofluidic protein separation, femtoliter-droplet mass spectrometry, nanopore-confined electrochemical sensing, digital nanopore virus detection and nonlinear electrokinetics in nanopores. This session will enable us to merge novel ideas for the exploration of a pathway forward for the advancement of current nanobiosensor technology. 

Digestion and Separation of pL Protein Sample Utilizing Nanofluidics, Kyojiro Morikawa, Institute of NanoEngineering and MicroSystems (iNEMS), Department of Power Mechanical Engineering National Tsing Hua University, Hsinchu, Taiwan, Collaborative Research Organization for Micro and Nano Multifunctional Devices (NMfD), The University of Tokyo, Tokyo, Japan

Femtoliter-Droplet Shooter by Gas/Liquid Nanofluidics for an Interface of Mass Spectrometry, Yutaka Kazoe Department of System Design Engineering, Faculty of Science and Technology, Keio University, Kanagawa, Japan

Glass Nanopore Confined Electrochemical Sensing at Single Entity Level, Ru-Jia Yu, Yi-Lun Ying, Yi-Tao Long, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, P. R. China

Nanopore Sensing for Single-Virus Detections to Digital Infection Diagnosis, Makusu Tsutsui The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

Transport-Induced-Charge Electrokinetics in Nanopores, Wei-Lun Hsu, Zhixuan Wang, Haoyu Wang, Hirofumi Daiguji, Department of Mechanical Engineering, The University of Tokyo, Tokyo, Japan

IS: Advanced Micro/Nano Photonics Technology

Session Chair: Guo-En Chang, National Chung Cheng University, Taiwan

Micro-nano photonics have long being important technologies for miniaturizing optical systems and enabling various applications including communications, computing, and sensing. This invited section provides a forum for researchers to discuss the cutting-edge research in micro/nano photonics technologies for a wide range of applications.

Bio-Intelligent Lasers for Healthcare Applications, Yu-Cheng Chen, School of Electrical and Electronics Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore

Nanostructured Inorganic Semiconductors for Advanced Optoelectronics, Munho Kim, School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore

Integrated on-chip nanolasers based on solution-processed perovskite quantum dots, Ya-Lun Ho, University of Tokyo, Japan

Plasmonic-enhanced Terahertz Tomography, Shang-Hua Yang, Department of Electrical Engineering, National Tsing Hua University, Taiwan

Fabrication of Photodetectors Based on Low-Dimensional Materials, Wei-Chen Tu, Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan

IS: NEMS for Human Sensing

Session Chair: Hiroyuki Kudo, Meiji University

In this session, highly active Japanese researchers will introduce the latest research status from fundamentals to applications of human sensing, which is accelerating toward a post-pandemic.We focused on non-invasive and minimally invasive biomonitoring for human sensing.

Sensing Your Mind by Wearable Devices: a Challenge of Neuroengineering for Human Well-being, Yumie Ono, Health Science and Medical Engineering Laboratory, Meiji University, Kawasaki, Japan., Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University, Kawasaki, Japan

Minimally Invasive Microperfusion System for Measurement of Subepidermal Biological Substances, Noriko Tsuruka, Graduate School of Engineering, Tohoku University, Miyagi, Japan

Conformal Printings for Stress-Free Human Monitoring: Sensor Elements Blended with the Environment, Ken-ichi Nomura, Sensing System Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan

Non-invasive Biosensing Systems for Personal Health Recording, Hiroyuki Kudo, Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University, Kawasaki, Kanagawa, Japan

Bioelectrical interfaces for enzyme-free biosensors, Toshiya Sakata, Department of Materials Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan

IS: Advanced Fabrication Technologies for Nano/Micro Systems

Session Chair: Yoshikazu HIRAI, Kyoto University

Current micro-nano fabrication technology has reached integration levels at which high-performance MEMS devices and sensitive sensors can be fabricated. The scope of this invited session covers new design, fabrication technology, characterization, and applications of devices and systems in micro- and nano-scales. This session is organized five energetic researchers in Japan and highlights recent advances in the field of fabrication technologies and the state of the art in Nano/Micro System applications.

Femtosecond Laser Direct Writing of Metal/Metal Oxide Composite Patterns for Sensor Applications, Mizue Mizoshiri, Nagaoka University of Technology, Japan

Rapid Prototyping of Microstructure Using Grayscale Lithography, Kentaro Totsu, Micro System Integration Center, Tohoku University, Japan

Development of Ultra-thin Glass and Its Application to Micro/Nanofluidics, Yo Tanaka, Laboratory for Integrated Biodevice, Center for Biosystems Dynamics Research (BDR), RIKEN, Japan

Z-axis Controllable Multi-Electrode-Layer Electrorotation Device Utilizing Levitation Effect, Yuki Okamoto, Sensing System Research Center, National Institute of Advanced Industrial Science and Technology, Japan

Alkali Metal Vapor Cells Fabricated with Three-Dimensional Microstructuring Technique for Miniature Atomic Clocks, Yoshikazu Hirai, Department of Mechanical Engineering and Science, Kyoto University, Japan

IS: Advanced Nanotool for NEMS

Session Chair: Koji Sugano, Kobe University 

Nanotechnology researches have been developed on the foundations of nanotechnological tools such as electron microscopy, atomic force microscopy (AFM), and various other observation and analytical technologies. These are still developing and are expected to lead to novel nanotechnologies. The electron microscopy is used for not only observation but also manipulation of biomolecules. Its combination with MEMS enables novel characterization of nanoscale physics. The plasmonic nanostructures will also open up novel technologies for analyzing biomolecules. The novel AFM provides the capability of nanoscale resolution visualization and interaction measurements in liquids. In this session, recent research activities on advanced nanotools are presented.

Molecular Mixed Reality Using Nano Resolution Virtual Cathode Display, Takayuki Hoshino, Department of Mechanical Science and Engineering, Hirosaki University at Hirosaki, Japan

MEMS Probes in Electron Microscope for Nanotribology, Tadashi Ishida, Department of Mechanical Engineering, Tokyo Institute of Technology, Kanagawa, Japan

Atomic-Scale Imaging of Surface and Interfacial Structures in Liquids by Frequency Modulation Atomic Force Microscopy, Naritaka Kobayashi, Department of Electronic Systems Engineering, School of Engineering, The University of Shiga Prefecture, Japan

Development of nanoendoscopy-AFM for visualizing intracellular nanostructures of living cells, Keisuke Miyazawa, Faculty of Frontier Engineering, Kanazawa University, Ishikawa, Japan, Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Ishikawa, Japan

Manipulation and detection of a single DNA oligomer using a gold nanoparticle dimer, Koji Sugano, Department of Mechanical Engineering, Graduate School of Engineering, Kobe University, Japan

IS: MEMS/NEMS Based Microfluidic and Medical Devices

Session Chair: Sang-Seok Lee, Tottori University, Japan

In this session, we focus on MEMS/NEMS based devices for medical and health care applications. This session consists of 5 invited talks such as 3 talks for microfluidics, 2 talks for medical devices. The cutting-edge research achievement will be presented in the session.

Minimally Invasive Medical Devices Utilizing Non-planar Photofabrication Techniques, Tadao Matsunaga, Faculty of Engineering, Tottori University, Tottori, Japan

Development of Ingestible Thermometer Charged by Gastric Acid Battery as a Next-Generation Healthcare Device, Shinya Yoshida, Graduate School of Engineering, Tohoku University, Sendai, Miyagi, Japan

Point-of-Care Finger-Actuated Microfluidic Devices, Je-Kyun Park, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, REPUBLIC OF KOREA, KAIST Institute for the NanoCentury, Daejeon, REPUBLIC OF KOREA, KAIST Institute for Health Science and Technology, Daejeon, REPUBLIC OF KOREA

Nanoparticle Polymer Composites for Microfluidics and BioMEMS, Bonnie L. Gray, Engineering Science, Faculty of Applied Sciences, Simon Fraser University, Burnaby, BC, Canada

Robust Processing of Multi-Step Reactions in Drops, Hee-Sun Han, Chemistry Department, University of Illinois at Urbana-Champaign, IL, USA, Center for Biophysics and Quantitative Biology, Urbana, IL, USA, Institute for Genomic Biology, Urbana, IL, USA

IS: Micro-/nano-structure-enabled Sensors

Session Chair: Faheng Zang, Shanghai Jiao Tong University, China 

Micro- and nano-scale structures and fabrication technology are increasingly used in creation of high-performance and multi-functional sensor platforms for health. These micro-/nano-structures-integrated sensors require minimal amount analyte, benefit from the high-surface-area sensing probes and exhibit ultra-high sensitivity. Researchers around the global are invited to this session to discuss micro-/nano-structures and advanced fabrication technologies. The topics include microneedles, CNT-modified electrochemical sensors, nanostructured receptors and transducers, 3D nanofabrication, and nanostructured-Si microcantilevers, as well as their applications in sensing.

Microneedle fabrication and applications, Bo Cui, Department of Electrical & Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada

Electrochemical sensing of biomolecules using carbon nanotube nanocomposites modified electrodes, Xiaoxue Xu¹, Wei Zheng²,

¹School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, 2007, NSW, Australia

^2.Institute of Corrosion Science and Surface Technology, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China

Versatile biosensing enabled by nanostructured transducers and receptors, Faheng Zang, Department of Micro/Nano Electronics, Shanghai Jiao Tong University, Shanghai, China

3-D Nanofabrication and Nanostructure Fine-tuning via Helium Ion Microscope, Huan Hu, ZJU-UIUC Institute, International Campus, Zhejiang University, Haining, Zhejiang Province, China., State Key laboratory of Fluidic Power & Mechanical Systems, Zhejiang University, Hangzhou, China

Nanostructured-Silicon Microcantilever Resonators for Multifunctional Sensing Applications, Jiushuai Xu, Institute of Semiconductor Technology (IHT), TU Braunschweig, Braunschweig, Germany, Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, Braunschweig, Germany